Dutkowski´s research on preservation-reperfusion injury of hepatic grafts (Editorial)

The Skeptik, 2017, Vol. 3. Pgs. 9-10.

Kukan M. Slovak Medical University, emeritus, Bratislava, Slovakia

Professor Dr. Phillip Dutkowski comes from Germany. At present, he works in University of Zurich.

His research started with oscillating liver perfusion, where he showed that ATP can be repleted prior to liver transplantation in the rat model (1-2). In acellular model of rat liver reperfusion, he showed that oscillating perfusion downregulated superoxide anion release (3). This suggests that Kupffer cells where downregulated by oscillating perfusion.

Then he introduced a model of hypothermic oxygen perfusion (HOPE) (4, see 5-7 for his reviews), in Professor PA Clavien´s Laboratory.

Finally, his was sucssesfull  in machine perfusion of human hepatic grafts, where he showed that HOPE saved graft failure and a need for liver retransplantation (8).

In conclusion, Professor Dr. Phillip Dutkowski belongs to one of world leading scientists in preservation-reperfusion injury of hepatic grafts.

REFERENCES

1. Dutkowski P, Schönfeld S, Odermatt B, Heinrich T, Junginger T. Rat liver preservation by hypothermic oscillating liver perfusion compared to simple cold storage. Cryobiology. 1998 Feb;36(1):61-70.

2. Dutkowski P, Odermatt B, Heinrich T, Schönfeld S, Watzka M, Winkelbach V, Krysiak M, Junginger T. Hypothermic oscillating liver perfusion stimulates ATP synthesis prior to transplantation J Surg Res. 1998 Dec;80(2):365-72.

3. Dutkowski P, Schönfeld S, Heinrich T, Watzka M, Winkelbach V, Krysiak M, Odermatt B, Junginger T.  Reduced oxidative stress during acellular reperfusion of the rat liver after hypothermic oscillating perfusion.Transplantation. 1999 Jul 15;68(1):44-50.

4. Dutkowski P, Furrer K, Tian Y, Graf R, Clavien PA. Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. Ann Surg. 2006 Dec;244(6):968-76; discussion 976-7.

5. Dutkowski P, de Rougemont O, Clavien PA. Machine perfusion for 'marginal' liver grafts. Am J Transplant. 2008 May;8(5):917-24. doi: 10.1111/j.1600-6143.2008.02165.x. Review.

6. de Rougemont O, Breitenstein S, Leskosek B, Weber A, Graf R, Clavien PA, Dutkowski P. One hour hypothermic oxygenated perfusion (HOPE) protects nonviable liver allografts donated after cardiac death. Ann Surg. 2009 Nov;250(5):674-83 

7. Dutkowski P, Linecker M, DeOliveira ML, Müllhaupt B, Clavien   Challenges to liver transplantation and strategies to improve outcomes. Gastroenterology. 2015 Feb;148(2):307-23. doi: 10.1053/j.gastro.2014.08.045. Epub 2014 Sep 16. Review.

8. Dutkowski P, Polak WG, Muiesan P, Schlegel A, Verhoeven CJ, Scalera I   First Comparison of Hypothermic Oxygenated PErfusion Versus Static Cold Storage of Human Donation After Cardiac Death Liver Transplants: An International-matched Case Analysis.Anals Surg. 2015 Nov;262(5):764-70